Clinical Studies

The High Desert Heart Institute human clinical study of ProArgi9.

“The most comprehensive human clinical study ever conducted on a nutritional supplement.”

In 2009 the High Desert Heart Institute concluded a comprehensive clinical study of ProArgi9.  HDHI was founded by Dr. Siva Arunasalam, who is an affiliate of Cedars-Sinai of Los Angeles and internationally respected for superior care of high-risk heart patients.

For this study 33 high-risk heart failure patients were selected. All patients in the study had reached the end of what medical science could do for them. They were at maximum drug levels, maximum supplemental oxygen and maximum therapy. 60% of these patients were on the heart-transplant list.

“There was nothing else for us to try, we had tried everything with these patients. All patients showed a tremendous improvement in many, many objective data points that only can be attributed to ProArgi9
Dr. Siva Arunasalam

To scientifically measure the effects of ProArgi9 plus every patient received extensive diagnostic testing for 13 weeks producing almost 7000 points of data. Each patient was given two scoops of ProArgi9 plus in the morning and two in the evening.

The results of the 90 day study were far more significant than anyone expected. Many of the patients were able to resume normal lives and the quality of life for all patients had improved dramatically. Full results of the study using ProArgi9 plus are currently being written up for publication in medical journals.

A few of the compelling results were as follows:

–  18% increase in HDL Cholesterol
–  40% decrease in triglycerides
–  8% Glucose reduction
–  25% decrease in c-reactive proteins
–  11% reduction in creatine levels
–  35% increase in magnesium levels (even though there is no magnesium in the product) magnesium is very important in improving heart health
–  Decreases in platelets in the blood
–  Albumin decreased by 70%
–  Bilirubin decreased significantly
–  Vitamin D levels increased by 183%
–  Systolic BP decreased by 13%
–  Diastolic BP decreased by 17%
–  Peripheral blood flow increased to the feet (an ankle reading) by 16%
–  CASP (Central Aortic Systolic Pressure) decreased by 6%
–  Pulmonary Hypertension dramatically improved
–  Quality of life measurements significantly improved for all participants

Dr. Siva Arunasalam, is the founder and attending Cardiologist at the Heart Institute of the High Desert in Victorville, California.
Curriculum Vitae

“I expected a marginal improvement in the symptoms…what we ended up seeing was remarkable, positive, remodeling of the heart, positive pulmonary artery changes, pulmonary vascular changes…
Dr. Siva Arunasalam

Dan Austin is the RN in charge of every patient in this study. He saw first hand the amazing results of ProArgi9 from the beginning to the end.



“I’ve been doing this type of work in critical care for well over 20 years and you see what congestive heart failure does. I have seen a dramatic, a dramatic reversal in Angelo’s symptoms.”
Dan Austin

Angelo Cici is a patient and part of the study. On Dec 20, 2008 Angelo had a massive heart failure with simultaneous renal failure, congestive heart failure, pulmonary heart failure and a pace maker failure. From this point on he was in and out of the emergency room. “I was so weak I couldn’t even open a bottle of water by myself and I had decided, I had had enough. I told the nurses I wanted all the IV’s removed and I just wanted to go home and die.”

“I was never going more than 5 days with out going back into the hospital emergency room until I started taking ProArgi9. … it’s been 6 months since I’ve been into a hospital. …I feel like I’m 40 years old again.”
Angelo Cici

The High Desert Heart Institute
Victorville, California USA
Clinical Trail Overview

• Based On Nobel Prize-Winning Science
• Usage of ProArgi-9 Plus formula as
• integrative arginine
• 33 High Risk Test Patients
• Commencement date of Clinical Study is Feb 2nd 2009


• Patients under direction of HDHI Physicians
• Each patient receives 10 grams am and 10 grams pm
• 30/60/90 day period data review on patients

Disease Category Subsets

• PVD (Peripheral Vascular Disease)
• Angina
• Malignant Hypertension
• Diabetes Mellitus
• Pulmonary Arterial Hypertension
• Erectile Dysfunction

Lab Tests (done on a weekly basis)

• CMP (Complete Metabolic Panel)
• CBC (Complete Blood Count)
• HgbA1c Hemoglobin 90 day test
• Full Lipid Panel
• Vitamin D3 levels
• Microalbumin
• LFT (Liver Function Test)
• BNP (B-Naturetic Peptide Levels)
• CRP (C-Reactive Protein)
• Echocardiogram
• CardioDynamic Analysis (BioZ)
• 6 Minute Walk Test
• Coronary Calcium Score:  (Computerized tomography)
• Coronary CT Angio IV Contrast
• Ankle – Brachial Index
• Cardio Pulsewave Analysis (B-Pro)
• Doppler Echo
• Blood Oxygen Saturation Levels  (APRIA Health)

he High Desert Heart Institute human clinical study of ProArgi9.